What are the Symptoms of Gout?

Gout is an acute, severe form of joint pain that causes swelling, inflammation, and tenderness. Arthrocentesis using synovial fluid analysis that shows extremely negative birefringent needlelike crystals under polarized lighting.

Acute disease can be treated with nonsteroidal anti-inflammatory drugs such as colchicine, corticosteroids, and interleukin-1 inhibits.

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Definition

Gout is a condition that causes hyperuricemia and deposition urate crystals, which can lead to attacks of acute inflammation arthritis, tophi around the joints and possible destruction of them, glomerular tubular and interstitial kidney disease, and urinary-uric acid stone formations. It usually affects the first and second toes (podagra), feet, ankle, knee, fingers and wrist. However, it can also affect other joints.

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What causes Gout caused by Uric Acid?

Uric acid is a substance that is produced in the liver. It comes from the metabolism purine, which is a type protein found in our food. Our body produces more uric acid the more purine we consume.

Humans lost the ability to make an enzyme called “uricase” during evolution. This enzyme transforms uric acids into allantoin. Allantoin is a substance that’s much more easily soluble in blood. Humans have higher levels of uric acid than other mammals.

Because most people can eliminate excess uric acid through their kidneys, our blood levels of uric acids do not reach dangerous levels. Women of reproductive age have lower levels due to estrogen’s influence on uric acid elimination. Despite the best efforts of our kidneys, our blood levels of uric acids are not at the limit of solubility. This causes small increases in concentration to precipitate (crystallization of uric acids in the tissues).

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Uric acid dissolves best at temperatures higher than 37 degrees Celsius, which is the blood temperature. Actually, the temperature in our joints is much lower than that. In some cases, it can reach 32 degrees Celsius. This favors crystal formation in these areas. (Tape your knee and compare the temperature to your legs or thighs with your knee). The tissues are deposited with sodium urate.

uric acid is dissolved in blood until levels of 7.0 mg/dl. The blood level of uric acid is 7.0 mg/dl. Above that, crystallization and deposition are possible in tissues. Crystallization can occur in even the most warm tissues such as skin if the blood concentration of urine acid continues to increase.

High Uric Acid Symptoms

Hyperuricemia (high blood uric acid) does not cause symptoms. More than 2/3 people with high levels of uric acid don’t know this. However, symptoms do not necessarily mean that high uric acid levels aren’t causing complications. Gout attacks and kidney stones containing uric acid are the most common.

Gout sufferers with a history report scaling of their hands and feet when their uric acid levels rise. There is no evidence that such a relationship exists. Scaling of the feet and hands is often caused by dry skin and not elevated uric acid.

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Gout Symptoms

Gout can be manifested as arthritis. Gout is a condition that causes inflammation in a joint. It can be characterized by redness, swelling, pain and heat.

Gout is a monoarthritis. This is arthritis that only affects one joint during a crisis. Gout affects the most the joints of the feet, particularly the first toe (thumb), and the knees.

Gout arthritis can be so severe that people are unable to cover their feet. The simple touch of the sheet against the inflamed area causes severe pain. You may experience fever and chills, which can mimic an infectious condition.

Gout attacks last for a few days before disappearing spontaneously. The time between the first and second crises can be up to two years. Gout attacks can become more severe and frequent if left untreated.

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